Manba
Function
Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides.
Pathway
Glycan metabolism; N-glycan degradation.
Sequence Similarities
Belongs to the glycosyl hydrolase 2 family.
Tissue Specificity
Highest level in liver, high levels in lung, testis, skin and spleen, moderate level in thymus. Activity found in plasma, kidney, liver, spleen, pancreas, brain, testis, epididymis, heart, lung and skeletal muscle.
Cellular localization
- Lysosome
Alternative names
Bmn, Manba, Beta-mannosidase, Lysosomal beta A mannosidase, Mannanase, Mannase