MAOA
Function
Catalyzes the oxidative deamination of primary and some secondary amine such as neurotransmitters, with concomitant reduction of oxygen to hydrogen peroxide and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues (PubMed:18391214, PubMed:20493079, PubMed:24169519, PubMed:8316221). Preferentially oxidizes serotonin (PubMed:20493079, PubMed:24169519). Also catalyzes the oxidative deamination of kynuramine to 3-(2-aminophenyl)-3-oxopropanal that can spontaneously condense to 4-hydroxyquinoline (By similarity).
Involvement in disease
Brunner syndrome
BRNRS
A form of X-linked non-dysmorphic mild intellectual disability. Male patients are affected by borderline intellectual deficit and exhibit abnormal behavior, including disturbed regulation of impulsive aggression. Obligate female carriers have normal intelligence and behavior.
None
The disease is caused by variants affecting the gene represented in this entry.
Sequence Similarities
Belongs to the flavin monoamine oxidase family.
Tissue Specificity
Heart, liver, duodenum, blood vessels and kidney.
Cellular localization
- Mitochondrion outer membrane
- Single-pass type IV membrane protein
- Cytoplasmic side
Alternative names
Amine oxidase [flavin-containing] A, Monoamine oxidase type A, MAO-A, MAOA