Map1a
Domain
The basic region containing the repeats may be responsible for the binding of MAP1A to microtubules.
Function
Structural protein involved in the filamentous cross-bridging between microtubules and other skeletal elements.
Post-translational modifications
Phosphorylated by CSNK1D.
LC2 is generated from MAP1A by proteolytic processing. It is free to associate with both MAP1A and MAP1B (By similarity).
Sequence Similarities
Belongs to the MAP1 family.
Tissue Specificity
Both isoforms highly expressed in brain, and to a lesser extent in embryo. Isoform 1 is also expressed at a low level in other tissues including heart and muscle.
Cellular localization
- Cytoplasm
- Cytoskeleton
Alternative names
Mtap1, Mtap1a, Map1a, Microtubule-associated protein 1A, MAP-1A