MAP1B
Domain
Has a highly basic region with many copies of the sequence KKEE and KKEI/V, repeated but not at fixed intervals, which is responsible for the binding of MAP1B to microtubules.
Function
Facilitates tyrosination of alpha-tubulin in neuronal microtubules (By similarity). Phosphorylated MAP1B is required for proper microtubule dynamics and plays a role in the cytoskeletal changes that accompany neuronal differentiation and neurite extension (PubMed:33268592). Possibly MAP1B binds to at least two tubulin subunits in the polymer, and this bridging of subunits might be involved in nucleating microtubule polymerization and in stabilizing microtubules. Acts as a positive cofactor in DAPK1-mediated autophagic vesicle formation and membrane blebbing.
Involvement in disease
Periventricular nodular heterotopia 9
PVNH9
A form of periventricular nodular heterotopia, a disorder resulting from a defect in the pattern of neuronal migration in which ectopic collections of neurons lie along the lateral ventricles of the brain or just beneath, contiguously or in isolated patches. PVNH9 is an autosomal dominant disorder with incomplete penetrance, characterized by impaired intellectual development, cognitive defects, learning disabilities, and behavior abnormalities. Some patients develop seizures.
None
The disease is caused by variants affecting the gene represented in this entry.
Deafness, autosomal dominant, 83
DFNA83
A form of non-syndromic, sensorineural hearing loss. Sensorineural hearing loss results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information. DNFA83 is characterized by progressive, mild to profound hearing loss.
None
The disease may be caused by variants affecting the gene represented in this entry.
Post-translational modifications
LC1 is generated from MAP1B by proteolytic processing.
S-nitrosylation at Cys-2464 enhances interaction with microtubules, and may act as an effector modification for neuronal nitric oxide synthase control of growth-cone size, growth-cone collapse and axon retraction.
Sequence Similarities
Belongs to the MAP1 family.
Cellular localization
- Cytoplasm
- Cytoskeleton
- Cytoplasm
- Synapse
- Cell projection
- Dendritic spine
- Colocalizes with DAPK1 in the microtubules and cortical actin fibers.
- MAP1 light chain LC1
- Cytoplasm
Alternative names
Microtubule-associated protein 1B, MAP-1B, MAP1B