Map2

Developmental stage

Expressed in neurons at 18.5 dpc (at protein level).

Isoform 3

Expressed in the brain at postnatal day 6 (PubMed:2770869). Expressed in the brain at postnatal day 7 (PubMed:2174050).

Function

The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.

Post-translational modifications

Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly. Isoform 3/MAP2c is probably phosphorylated by PKA at Ser-319, Ser-350 and Ser-382 and by FYN at Tyr-67. The interaction with KNDC1 enhances MAP2 threonine phosphorylation (By similarity).

Tissue Specificity

Isoform 2

Expressed in the liver.

Isoform 3

Expressed in the entorhinal cortex and hippocampal neuronal cell bodies.

Cellular localization

• Cytoplasm
• Cytoskeleton
• Cell projection
• Dendrite

Alternative names

Mtap2, Map2, Microtubule-associated protein 2, MAP-2

Database links

swissprot:P15146 entrezGene:25595

Other research areas

• Oncology