MAP2
GeneName
MAP2
Summary
MAP2, also known as MAP-2 or microtubule associated protein 2, is a 200kDa protein predominantly expressed in neurons. It is localised to various subcellular compartments including dendrites, axon hillocks, and the neuronal cell body. MAP2 plays a crucial role in the organisation of the microtubule cytoskeleton, contributing to dendrite development and morphogenesis. It binds to microtubules and interacts with other proteins such as calmodulin and tau, facilitating the structural integrity and transport functions within neuronal projections.
Importance
MAP2 is relevant to: - Neuronal development and plasticity, as it is involved in dendrite formation and the structural organisation of the cytoskeleton - Neurodegenerative diseases, where alterations in MAP2 expression and function may contribute to dendritic atrophy and synaptic loss - Understanding the mechanisms of synaptic transmission through its role in regulating transport of synaptic vesicles and organelles - Research into the cellular mechanisms underlying cognitive functions and memory, given its critical involvement in neuron morphology and connectivity
Top Products
For researchers investigating MAP2, we recommend two excellent primary antibodies that cater to a variety of applications. The first is the highly regarded polyclonal antibody, Anti-MAP2 antibody - Neuronal Marker (ab5392), which has garnered 1045 citations, underscoring its reliability in the field. This antibody is particularly effective for immunocytochemistry (ICC), immunohistochemistry (IHC), and western blotting (WB). Additionally, we offer the recombinant antibody, Anti-MAP2 antibody [EPR19691] - Neuronal Marker (ab183830). This product has been validated for ICC, IHC, and flow cytometry (FC), making it a versatile option for researchers seeking consistent performance across experiments. With 68 citations, it is also gaining traction in the research community. Together, these antibodies provide robust tools for studying MAP2 in various experimental contexts.
Abcam Product Citation Summary
The data indicates a strong focus on the use of MAP2 antibodies in various studies related to neuronal health, differentiation, and pathology across different species, particularly in mouse and rat models. The applications include immunohistochemistry, immunofluorescence, and immunocytochemistry, highlighting the importance of MAP2 as a neuronal marker in research on neurodegenerative diseases, synaptic function, and neuronal development.
Abcam Product Citation Table
Function
The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.
Post-translational modifications
Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly (By similarity). Isoform 2 is probably phosphorylated by PKA at Ser-323, Ser-354 and Ser-386 and by FYN at Tyr-67. The interaction with KNDC1 enhances MAP2 threonine phosphorylation (By similarity).
Cellular localization
- Cytoplasm
- Cytoskeleton
- Cell projection
- Dendrite
Alternative names
Microtubule-associated protein 2, MAP-2, MAP2
Database links
swissprot:P11137 entrezGene:4133 omim:157130
Other research areas
- Oncology