Map2

The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.

Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly (By similarity). Isoform 2 is probably phosphorylated by PKA at Ser-323, Ser-354 and Ser-386 and by FYN at Tyr-67. The interaction with KNDC1 enhances MAP2 threonine phosphorylation (By similarity).

• Cytoplasm
• Cytoskeleton
• Cell projection
• Dendrite

Microtubule-associated protein 2, MAP-2, MAP2

• entrezGene:4133
• omim:157130
• swissprot:P11137

Proteins

Immunology & Infectious Disease

• Oncology

199526Da