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Methionine Aminopeptidase 2/p67

Function

The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.

Post-translational modifications

Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly (By similarity). Isoform 2 is probably phosphorylated by PKA at Ser-323, Ser-354 and Ser-386 and by FYN at Tyr-67. The interaction with KNDC1 enhances MAP2 threonine phosphorylation (By similarity).

Cellular localization

  • Cytoplasm
  • Cytoskeleton
  • Cell projection
  • Dendrite

Alternative names

  • Microtubule-associated protein 2
  • MAP-2
  • MAP2

Target type

Proteins

Primary research area

Neuroscience

Other research areas

  • Oncology

Molecular weight

199526Da