MAP3K1 phospho T1400
Function
Component of a protein kinase signal transduction cascade (PubMed:9808624). Activates the ERK and JNK kinase pathways by phosphorylation of MAP2K1 and MAP2K4 (PubMed:9808624). May phosphorylate the MAPK8/JNK1 kinase (PubMed:17761173). Activates CHUK and IKBKB, the central protein kinases of the NF-kappa-B pathway (PubMed:9808624).
Involvement in disease
46,XY sex reversal 6
SRXY6
A disorder of sex development. Affected individuals have a 46,XY karyotype but present as phenotypically normal females.
None
The disease is caused by variants affecting the gene represented in this entry.
Post-translational modifications
Autophosphorylated.
Sequence Similarities
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Alternative names
MAPKKK1, MEKK, MEKK1, MAP3K1, Mitogen-activated protein kinase kinase kinase 1, MAPK/ERK kinase kinase 1, MEK kinase 1, MEKK 1