MAP3K13
Function
Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. Acts synergistically with PRDX3 to regulate the activation of NF-kappa-B in the cytosol. This activation is kinase-dependent and involves activating the IKK complex, the IKBKB-containing complex that phosphorylates inhibitors of NF-kappa-B.
Post-translational modifications
Autophosphorylated on serine and threonine residues.
Sequence Similarities
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Tissue Specificity
Expressed in the adult brain, liver, placenta and pancreas, with expression strongest in the pancreas.
Cellular localization
- Cytoplasm
- Membrane
- Peripheral membrane protein
Alternative names
LZK, MAP3K13, Mitogen-activated protein kinase kinase kinase 13, Leucine zipper-bearing kinase, Mixed lineage kinase, MLK