MAP3K2
Function
Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 (By similarity). Plays a role in caveolae kiss-and-run dynamics.
Post-translational modifications
Autophosphorylated.
Ubiquitination by XIAP/BIRC4 does not lead to proteasomal degradation.
Sequence Similarities
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Cellular localization
- Cytoplasm
- Nucleus
- Upon EGF stimulation, translocates into the nucleus.
Alternative names
MAPKKK2, MEKK2, MAP3K2, Mitogen-activated protein kinase kinase kinase 2, MAPK/ERK kinase kinase 2, MEK kinase 2, MEKK 2