MAP3K4
Function
Component of a protein kinase signal transduction cascade. Activates the CSBP2, P38 and JNK MAPK pathways, but not the ERK pathway. Specifically phosphorylates and activates MAP2K4 and MAP2K6.
Sequence Similarities
Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.
Tissue Specificity
Expressed at high levels in heart, placenta, skeletal muscle and pancreas, and at lower levels in other tissues.
Cellular localization
- Cytoplasm
- Perinuclear region
- Localized in perinuclear vesicular-like structures, probably Golgi-associated vesicles.
Alternative names
KIAA0213, MAPKKK4, MEKK4, MTK1, MAP3K4, Mitogen-activated protein kinase kinase kinase 4, MAP three kinase 1, MAPK/ERK kinase kinase 4, MEK kinase 4, MEKK 4