MAP4
Function
Non-neuronal microtubule-associated protein. Promotes microtubule assembly.
Post-translational modifications
Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly (By similarity). Phosphorylation on Ser-787 negatively regulates MAP4 activity to promote microtubule assembly. Isoform 3 is phosphorylated on Ser-337 and Ser-338.
Cellular localization
- Cytoplasm
- Cytoskeleton
- Cytoplasm
- Cytoskeleton
- Microtubule organizing center
- Recruitment to microtubule is inhibited by microtubules polyglutamylation.
Alternative names
Microtubule-associated protein 4, MAP-4, MAP4