MAP4

Non-neuronal microtubule-associated protein. Promotes microtubule assembly.

Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly (By similarity). Phosphorylation on Ser-787 negatively regulates MAP4 activity to promote microtubule assembly. Isoform 3 is phosphorylated on Ser-337 and Ser-338.

• Cytoplasm
• Cytoskeleton
• Cytoplasm
• Cytoskeleton
• Microtubule organizing center
• Recruitment to microtubule is inhibited by microtubules polyglutamylation.

Microtubule-associated protein 4, MAP-4, MAP4

• entrezGene:4134
• omim:157132
• swissprot:P27816

Proteins

Immunology & Infectious Disease

121005Da