MARCHF3
Domain
The RING-CH-type zinc finger domain is required for E3 ligase activity.
Function
E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.
Pathway
Protein modification; protein ubiquitination.
Cellular localization
- Cytoplasmic vesicle membrane
- Multi-pass membrane protein
- Early endosome membrane
- Multi-pass membrane protein
Alternative names
MARCH3, RNF173, MARCHF3, E3 ubiquitin-protein ligase MARCHF3, Membrane-associated RING finger protein 3, Membrane-associated RING-CH protein III, RING finger protein 173, RING-type E3 ubiquitin transferase MARCHF3, MARCH-III