MARCO

Function

Pattern recognition receptor (PRR) which binds Gram-positive and Gram-negative bacteria (PubMed:9468508). Also plays a role in binding of unopsonized particles by alveolar macrophages (By similarity). Binds to the secretoglobin SCGB3A2 (PubMed:12847263).

Post-translational modifications

N-glycosylated.

Tissue Specificity

Expressed in alveolar macrophages (at protein level). Detected in macrophages from various tissues including thymus, kidney, Kupffer cells of liver, and spleen (PubMed:9468508).

Cellular localization

• Cell membrane
• Single-pass type II membrane protein

Alternative names

SCARA2, MARCO, Macrophage receptor MARCO, Macrophage receptor with collagenous structure, Scavenger receptor class A member 2

Database links

swissprot:Q9UEW3 omim:604870 entrezGene:8685

Other research areas

• Immuno-oncology