MARCO

Function

Pattern recognition receptor (PRR) which binds Gram-positive and Gram-negative bacteria (PubMed:7867067). Also plays a role in binding of unopsonized particles by alveolar macrophages (By similarity). Binds to the secretoglobin SCGB3A2 (By similarity).

Post-translational modifications

N-glycosylated.

Tissue specificity

Expressed in subpopulations of macrophages in the spleen and the medullary cord of lymph nodes (at protein level).

Cellular localization

• Cell membrane
• Single-pass type II membrane protein

Alternative names

• Macrophage receptor MARCO
• Macrophage receptor with collagenous structure
• Marco

Database links

• entrezGene:17167
• swissprot:Q60754

Target type

Proteins

Primary research area

Immunology & Infectious Disease

Other research areas

• Immuno-oncology

Molecular weight

52730Da