Marco

Function

Pattern recognition receptor (PRR) which binds Gram-positive and Gram-negative bacteria (PubMed:7867067). Also plays a role in binding of unopsonized particles by alveolar macrophages (By similarity). Binds to the secretoglobin SCGB3A2 (By similarity).

Post-translational modifications

N-glycosylated.

Tissue Specificity

Expressed in subpopulations of macrophages in the spleen and the medullary cord of lymph nodes (at protein level).

Cellular localization

• Cell membrane
• Single-pass type II membrane protein

Alternative names

Macrophage receptor MARCO, Macrophage receptor with collagenous structure, Marco

Database links

swissprot:Q60754 entrezGene:17167

Other research areas

• Immuno-oncology