MAST2
Function
Appears to link the dystrophin/utrophin network with microtubule filaments via the syntrophins. Phosphorylation of DMD or UTRN may modulate their affinities for associated proteins. Functions in a multi-protein complex in spermatid maturation. Regulates lipopolysaccharide-induced IL-12 synthesis in macrophages by forming a complex with TRAF6, resulting in the inhibition of TRAF6 NF-kappa-B activation (By similarity).
Post-translational modifications
Phosphorylated and ubiquitinated. N-terminal ubiquitination leads to degradation of MAST2 by proteasome-mediated proteolysis. N-terminal phosphorylation appears to be a prerequisite for ubiquitination (By similarity).
Sequence Similarities
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Tissue Specificity
Abundant in the testis.
Cellular localization
- Cytoplasm
- Cytoskeleton
- Cell membrane
- Peripheral membrane protein
- Cytoplasmic side
- Recruited to the sub-membranous area on interaction with CDHR2.
Alternative names
KIAA0807, MAST205, MAST2, Microtubule-associated serine/threonine-protein kinase 2