MAT2B/TGR

Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine (PubMed:10644686, PubMed:23189196, PubMed:25075345). Can bind NADP (in vitro) (PubMed:23189196, PubMed:23425511).

Amino-acid biosynthesis; S-adenosyl-L-methionine biosynthesis; S-adenosyl-L-methionine from L-methionine: step 1/1.

Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.

Widely expressed.

TGR, MSTP045, Nbla02999, UNQ2435/PRO4995, MAT2B, Methionine adenosyltransferase 2 subunit beta, Methionine adenosyltransferase II beta, Putative dTDP-4-keto-6-deoxy-D-glucose 4-reductase, MAT II beta

• entrezGene:27430
• omim:605527
• swissprot:Q9NZL9

Proteins

Immunology & Infectious Disease

37552Da