MATK
Function
Could play a significant role in the signal transduction of hematopoietic cells. May regulate tyrosine kinase activity of SRC-family members in brain by specifically phosphorylating their C-terminal regulatory tyrosine residue which acts as a negative regulatory site. It may play an inhibitory role in the control of T-cell proliferation.
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily.
Tissue Specificity
Expressed in various myeloid cell lines, detected in brain and lung.
Cellular localization
- Cytoplasm
- Membrane
- In platelets, 90% of MATK localizes to the membrane fraction, and translocates to the cytoskeleton upon thrombin stimulation.
Alternative names
CTK, HYL, MATK, Megakaryocyte-associated tyrosine-protein kinase, CSK homologous kinase, Hematopoietic consensus tyrosine-lacking kinase, Protein kinase HYL, Tyrosine-protein kinase CTK, CHK