MAU2
Function
Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with NIPBL/SCC2 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28167679). Plays a role in sister chromatid cohesion and normal progression through prometaphase (PubMed:16682347, PubMed:16802858).
Sequence Similarities
Belongs to the SCC4/mau-2 family.
Cellular localization
- Nucleus
- Nucleoplasm
- Nucleus
- Chromosome
- Binds to chromatin from the end of mitosis until prophase.
Alternative names
KIAA0892, SCC4, MAU2, MAU2 chromatid cohesion factor homolog, MAU-2, Cohesin loading complex subunit SCC4 homolog