MB
GeneName
MB
Summary
Myoglobin, a 17kDa haem-containing protein, is primarily located in the cytosol and sarcoplasm of muscle cells, where it plays a crucial role in oxygen storage and transport. It binds to oxygen and acts as an oxygen carrier, facilitating its diffusion within muscle tissues. Myoglobin is also involved in the removal of superoxide radicals, contributing to cellular protection against oxidative stress. Additionally, it participates in biological processes such as heart development and the differentiation of enucleate erythrocytes and brown fat cells.
Importance
Myoglobin is relevant to: - Muscle physiology and metabolism due to its role in oxygen transport and storage - Understanding hypoxia responses in tissues, particularly in cardiac and skeletal muscles - Investigating muscle disorders and conditions related to oxygen deficiency - Research on oxidative stress and its implications in various diseases
Top Products
For researchers investigating myoglobin (MB), we highly recommend the top-selling recombinant antibody, Anti-Myoglobin antibody [EP3081Y] (ab77232). This well-cited antibody has garnered 46 citations, reflecting its reliability and trust within the scientific community. It has been validated for use in several applications, including Western blotting (WB), immunohistochemistry (IHC), and immunocytochemistry (ICC), making it a versatile tool for your research needs. The recombinant nature of this antibody ensures batch-to-batch consistency, providing confidence in your experimental results. "The Human Myoglobin ELISA Kit (ab171580), supported by 10 citations, is an excellent option for researchers looking to accurately measure myoglobin levels in their samples."
Abcam Product Citation Summary
The data indicates that the Abcam antibody ab77232 was utilised in multiple studies focusing on myoglobin (MB) in Rattus norvegicus. The research primarily investigated the effects of myricetin on muscle fibre types and the composition of muscle fibre types, highlighting the relevance of MB in muscle physiology.
Abcam Product Citation Table
Function
Monomeric heme protein which primary function is to store oxygen and facilitate its diffusion within muscle tissues. Reversibly binds oxygen through a pentacoordinated heme iron and enables its timely and efficient release as needed during periods of heightened demand (PubMed:30918256, PubMed:34679218). Depending on the oxidative conditions of tissues and cells, and in addition to its ability to bind oxygen, it also has a nitrite reductase activity whereby it regulates the production of bioactive nitric oxide (PubMed:32891753). Under stress conditions, like hypoxia and anoxia, it also protects cells against reactive oxygen species thanks to its pseudoperoxidase activity (PubMed:34679218).
Involvement in disease
Myopathy, sarcoplasmic body
MYOSB
An autosomal dominant, slowly progressive muscle disorder manifesting in adulthood with proximal and axial weakness that progresses to involve distal muscles. Patients may lose ambulation after a long disease course, and some individuals develop respiratory or cardiac symptoms. Muscle pathology features include sarcoplasmic bodies in skeletal and cardiac muscles.
None
The disease is caused by variants affecting the gene represented in this entry.
Sequence Similarities
Belongs to the globin family.
Cellular localization
- Cytoplasm
- Sarcoplasm
Alternative names
Myoglobin, Nitrite reductase MB, Pseudoperoxidase MB, MB