MBL2
GeneName
MBL2
Summary
MBL2, also known as MBL or mannose binding lectin, is a 26 kDa protein that is secreted and functions primarily in the extracellular region. It is involved in the innate immune response and acts as a pattern recognition receptor that binds to specific carbohydrates, such as D-mannose, on the surface of pathogens. MBL2 plays a crucial role in the activation of the complement system via the lectin pathway, facilitating opsonization and phagocytosis of microbes. It is expressed in various tissues and contributes to the acute-phase response during infections and inflammatory processes.
Importance
MBL2 is relevant to: - The antiviral innate immune response through its role in recognising and binding to pathogens. - The complement activation pathways, particularly the lectin pathway, which are vital for opsonization and clearance of bacteria. - The defence response to Gram-positive bacteria, highlighting its importance in combating specific infections. - The regulation of oxidative stress responses, which can impact various disease states and inflammatory conditions.
Top Products
For researchers investigating MBL2, we recommend two primary antibodies that stand out for their performance and reliability. The first is the well-cited monoclonal antibody, Anti-Mannan Binding Lectin/MBL antibody [3B6] (ab23457), which has garnered 23 citations and is particularly effective for immunohistochemistry (IHC). This antibody is a trusted choice for those looking to study MBL2 in tissue samples.Additionally, we offer the recombinant antibody, Anti-MBL1+MBL2 antibody [EPR18381-156] (ab190834), which has been validated for use in both Western blotting (WB) and IHC. With 2 citations, this product provides researchers with the batch-to-batch consistency that recombinant antibodies are known for, making it an excellent option for various experimental needs. Together, these antibodies provide robust tools for studying MBL2 in different contexts. The Recombinant Human Mannan Binding Lectin/MBL protein (His tag) ELISA Kit (ab229367) is an excellent option for researchers looking to study MBL2 in their experiments.
Abcam Product Citation Summary
The data indicates that the MBL2 target has been studied in the context of human placental protein, specifically focusing on its differential expression in term placenta. This suggests a potential role of MBL2 in placental biology and its implications in pregnancy.
Abcam Product Citation Table
Domain
The coiled-coil domain mediates trimerization.
Function
Calcium-dependent lectin involved in innate immune defense (PubMed:35102342). Binds mannose, fucose and N-acetylglucosamine on different microorganisms and activates the lectin complement pathway. Binds to late apoptotic cells, as well as to apoptotic blebs and to necrotic cells, but not to early apoptotic cells, facilitating their uptake by macrophages. May bind DNA. Upon SARS coronavirus-2/SARS-CoV-2 infection, activates the complement lectin pathway which leads to the inhibition SARS-CoV-2 infection and a reduction of the induced inflammatory response (PubMed:35102342).
Tissue Specificity
Plasma protein produced mainly in the liver.
Cellular localization
- Secreted
Alternative names
COLEC1, MBL, MBL2, Mannose-binding protein C, MBP-C, Collectin-1, MBP1, Mannan-binding protein, Mannose-binding lectin