MBOAT4
Function
Catalyzes ghrelin acylation at 'Ser-3' using preferentially octanoyl-CoA, hexanoyl-CoA and decanoyl-CoA as acyl-CoA donors leading to ghrelin activity (PubMed:18443287, PubMed:24045953, PubMed:25562443, PubMed:28134508). In vitro uses also acyl-CoA donors of different lengths from short-chain (C2) to long-chain fatty acids (C16) knowing that acyl-CoA donors from butanoyl-CoA (C4) to dodecanoyl-CoA (C12) are more efficient compared to longer acyl-CoA donors, such as myristoyl-CoA (C14) and palmitoyl-CoA (C16) that are not efficient (PubMed:18443287).
Post-translational modifications
Not glycosylated.
Sequence Similarities
Belongs to the membrane-bound acyltransferase family.
Tissue Specificity
Expressed predominantly in stomach with moderate levels in pancreas and relatively low levels in most other tissues.
Cellular localization
- Endoplasmic reticulum membrane
- Multi-pass membrane protein
Alternative names
GOAT, OACT4, FKSG89, MBOAT4, Ghrelin O-acyltransferase, Membrane-bound O-acyltransferase domain-containing protein 4, O-acyltransferase domain-containing protein 4