Melanocyte-stimulating hormone receptor

Receptor for MSH (alpha, beta and gamma) and ACTH (PubMed:11442765, PubMed:11707265, PubMed:1325670, PubMed:1516719, PubMed:8463333). The activity of this receptor is mediated by G proteins which activate adenylate cyclase (PubMed:11707265, PubMed:1325670, PubMed:16463023, PubMed:19737927). Mediates melanogenesis, the production of eumelanin (black/brown) and phaeomelanin (red/yellow), via regulation of cAMP signaling in melanocytes (PubMed:31097585).

Melanoma, cutaneous malignant 5

CMM5

A malignant neoplasm of melanocytes, arising de novo or from a pre-existing benign nevus, which occurs most often in the skin but may also involve other sites.

None

Disease susceptibility is associated with variants affecting the gene represented in this entry.

Belongs to the G-protein coupled receptor 1 family.

Expressed in melanocytes (PubMed:1325670, PubMed:31097585). Expressed in corticoadrenal tissue (PubMed:1325670).

• Cell membrane
• Multi-pass membrane protein

MSHR, MC1R, Melanocyte-stimulating hormone receptor, MSH-R, Melanocortin receptor 1, MC1-R

• entrezGene:4157
• omim:155555
• swissprot:Q01726

Proteins

Immunology & Infectious Disease

34706Da