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MC3-R

Function

Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Required for expression of anticipatory patterns of activity and wakefulness during periods of limited nutrient availability and for the normal regulation of circadian clock activity in the brain.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Tissue specificity

Brain, placental, and gut tissues.

Cellular localization

  • Cell membrane
  • Multi-pass membrane protein

Alternative names

  • Melanocortin receptor 3
  • MC3-R
  • MC3R

Target type

Proteins

Molecular weight

36043Da