MCC
Function
Candidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b-catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation (PubMed:18591935, PubMed:19555689, PubMed:22480440). Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity (PubMed:24824780).
Sequence Similarities
Belongs to the MCC family.
Tissue Specificity
Expressed in a variety of tissues.
Cellular localization
- Cell membrane
- Cell projection
- Lamellipodium
- Nucleus
- Cytoplasm
- Colocalizes with actin at the leading edge of polarized cells.
Alternative names
Colorectal mutant cancer protein, Protein MCC, MCC