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MCHR-1

Function

Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Tissue specificity

Highest level in brain, particularly in the frontal cortex and hypothalamus, lower levels in the liver and heart.

Cellular localization

  • Cell membrane
  • Multi-pass membrane protein

Alternative names

  • Melanin-concentrating hormone receptor 1
  • MCH receptor 1
  • MCH-R1
  • MCHR-1
  • G-protein coupled receptor 24
  • MCH-1R
  • SLC-1
  • Somatostatin receptor-like protein
  • MCH1R
  • MCHR
  • SLC1
  • GPR24
  • MCHR1

Target type

Proteins

Molecular weight

45963Da