MCM3

Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:32453425). Required for the entry in S phase and for cell division (Probable).

Acetylated by MCM3AP.

O-glycosylated (O-GlcNAcylated), in a cell cycle-dependent manner.

Belongs to the MCM family.

• Nucleus
• Chromosome
• Associated with chromatin before the formation of nuclei and detaches from it as DNA replication progresses.

DNA replication licensing factor MCM3, DNA polymerase alpha holoenzyme-associated protein P1, P1-MCM3, RLF subunit beta, p102, MCM3

• entrezGene:4172
• omim:602693
• swissprot:P25205

Proteins

Immunology & Infectious Disease

90981Da