Mcpt4
Function
Has chymotrypsin-like activity. Hydrolyzes the amide bonds of synthetic substrates having Tyr and Phe residues at the P1 position. Preferentially hydrolyzes the 'Tyr-4-|-Ile-5' bond of angiotensin I and the 'Phe-20-|-Ala-21' bond of amyloid beta-protein, and is less active towards the 'Phe-8-|-His-9' bond of angiotensin I and the 'Phe-4-|-Ala-5' and 'Tyr-10-|-Glu-11' bonds of amyloid beta-protein. Involved in thrombin regulation and fibronectin processing.
Sequence Similarities
Belongs to the peptidase S1 family. Granzyme subfamily.
Tissue Specificity
Submucosal mast cells. In femoral muscle, detected in myocytes but not in mast cells.
Alternative names
Mast cell protease 4, mMCP-4, MSMCP, Myonase, Serosal mast cell protease, Mcpt4