MCRS1
Developmental stage
Cell-cycle regulated: levels are highest early in S phase; not detectable in G2.
Function
Modulates the transcription repressor activity of DAXX by recruiting it to the nucleolus (PubMed:11948183). As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues (PubMed:20018852). Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. May also be an inhibitor of TERT telomerase activity (PubMed:15044100). Binds to G-quadruplex structures in mRNA (PubMed:16571602). Binds to RNA homomer poly(G) and poly(U) (PubMed:16571602).
Post-translational modifications
Ubiquitinated by UBR5 when not assembled in the INO80 complex, leading to its degradation: UBR5 recognizes and binds a degron that is not accessible when MCRS1 is part of the INO80 complex.
Tissue Specificity
Detected in testis, and at lower levels in spleen, thymus, prostate, uterus, small intestine, colon and leukocytes.
Cellular localization
- Nucleus
- Nucleus
- Nucleolus
- Cytoplasm
- In microspherules in the nucleolus.
Alternative names
INO80Q, MSP58, MCRS1, Microspherule protein 1, 58 kDa microspherule protein, Cell cycle-regulated factor p78, INO80 complex subunit J, MCRS2