MED14
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Sequence Similarities
Belongs to the Mediator complex subunit 14 family.
Tissue Specificity
Ubiquitous.
Cellular localization
- Nucleus
Alternative names
ARC150, CRSP2, CXorf4, DRIP150, EXLM1, RGR1, TRAP170, MED14, Mediator of RNA polymerase II transcription subunit 14, Activator-recruited cofactor 150 kDa component, Cofactor required for Sp1 transcriptional activation subunit 2, Mediator complex subunit 14, RGR1 homolog, Thyroid hormone receptor-associated protein complex 170 kDa component, Transcriptional coactivator CRSP150, Vitamin D3 receptor-interacting protein complex 150 kDa component, CRSP complex subunit 2, hRGR1, Trap170