MED15
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for cholesterol-dependent gene regulation. Positively regulates the Nodal signaling pathway.
Post-translational modifications
Ubiquitinated by TRIM11, leading to proteasomal degradation.
Sequence Similarities
Belongs to the Mediator complex subunit 15 family.
Tissue Specificity
Expressed in all tissues examined, including heart, brain, lung, spleen, thymus, pancreas, blood leukocyte and placenta. However, the level of expression varied, with highest expression in the placenta and peripheral blood and lowest in the pancreas and kidney.
Cellular localization
- Cytoplasm
- Nucleus
Alternative names
ARC105, CTG7A, PCQAP, TIG1, TNRC7, MED15, Mediator of RNA polymerase II transcription subunit 15, Activator-recruited cofactor 105 kDa component, CTG repeat protein 7a, Mediator complex subunit 15, Positive cofactor 2 glutamine/Q-rich-associated protein, TPA-inducible gene 1 protein, Trinucleotide repeat-containing gene 7 protein, PC2 glutamine/Q-rich-associated protein, TIG-1