MED18
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Sequence Similarities
Belongs to the Mediator complex subunit 18 family.
Cellular localization
- Nucleus
Alternative names
Mediator of RNA polymerase II transcription subunit 18, Mediator complex subunit 18, p28b, MED18