MED24
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Sequence Similarities
Belongs to the Mediator complex subunit 24 family.
Tissue Specificity
Ubiquitous. Abundant in skeletal muscle, heart and placenta.
Cellular localization
- Nucleus
Alternative names
ARC100, CRSP4, DRIP100, KIAA0130, THRAP4, TRAP100, MED24, Mediator of RNA polymerase II transcription subunit 24, Activator-recruited cofactor 100 kDa component, Cofactor required for Sp1 transcriptional activation subunit 4, Mediator complex subunit 24, Thyroid hormone receptor-associated protein 4, Thyroid hormone receptor-associated protein complex 100 kDa component, Vitamin D3 receptor-interacting protein complex 100 kDa component, CRSP complex subunit 4, Trap100, hTRAP100