MED28
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May be part of a complex containing NF2/merlin that participates in cellular signaling to the actin cytoskeleton downstream of tyrosine kinase signaling pathways.
Sequence Similarities
Belongs to the Mediator complex subunit 28 family.
Tissue Specificity
Widely expressed. Highly expressed in vascular tissues such as placenta, testis and liver.
Cellular localization
- Nucleus
- Cytoplasm
- Membrane
- Peripheral membrane protein
- According to PubMed:15467741, it is cytoplasmic and mainly membrane-associated.
Alternative names
EG1, FKSG20, MED28, Mediator of RNA polymerase II transcription subunit 28, Endothelial-derived protein 1, Mediator complex subunit 28, Merlin and Grb2-interacting cytoskeletal protein, Tumor angiogenesis marker EG-1, Magicin