MED29
Function
Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
Sequence Similarities
Belongs to the Mediator complex subunit 29 family.
Tissue Specificity
Widely expressed in embryo and adult.
Cellular localization
- Nucleus
Alternative names
IXL, MED29, Mediator of RNA polymerase II transcription subunit 29, Intersex-like protein, Mediator complex subunit 29