Melatonin receptor type 1A
Function
High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.
Sequence Similarities
Belongs to the G-protein coupled receptor 1 family.
Tissue Specificity
Expressed in hypophyseal pars tuberalis and hypothalamic suprachiasmatic nuclei (SCN). Hippocampus.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
Alternative names
Melatonin receptor type 1A, Mel-1A-R, Mel1a receptor, MTNR1A