METAP1
Function
Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle.
Sequence Similarities
Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
Cellular localization
- Cytoplasm
Alternative names
KIAA0094, METAP1, Methionine aminopeptidase 1, MAP 1, MetAP 1, Peptidase M 1