METAP1D
Function
Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed (By similarity). May play a role in colon tumorigenesis.
Sequence Similarities
Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.
Tissue Specificity
Overexpressed in colon cancer cell lines and colon tumors as compared to normal tissues (at protein level).
Cellular localization
- Mitochondrion
Alternative names
MAP1D, METAP1D, MAP 1D, MetAP 1D, Peptidase M 1D