Mettl2
Function
S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU) (PubMed:28655767). N(3)-methylcytidine methylation by METTL2 requires the N6-threonylcarbamoylation of tRNA (t6A37) by the EKC/KEOPS complex as prerequisite (By similarity).
Sequence Similarities
Belongs to the methyltransferase superfamily. METL family.
Cellular localization
- Cytoplasm
Alternative names
D11Ertd768e, tRNA N(3)-cytidine methyltransferase METTL2, Methyltransferase-like protein 2