MEX3C
Domain
Binds RNA through its KH domains.
Function
E3 ubiquitin ligase responsible for the post-transcriptional regulation of common HLA-A allotypes. Binds to the 3' UTR of HLA-A2 mRNA, and regulates its levels by promoting mRNA decay. RNA binding is sufficient to prevent translation, but ubiquitin ligase activity is required for mRNA degradation.
Involvement in disease
Genetic variations in MEX3C may be associated with susceptibility to essential hypertension.
Tissue Specificity
Highest levels found in fetal brain and testis. Also expressed in thymus, salivary gland and uterus. Highly expressed in cells of the innate immune system, in particular activated NK cells. Week expression in the intestine.
Cellular localization
- Cytoplasm
- Nucleus
- Predominantly expressed in the cytoplasm and shuttles between the cytoplasm and the nucleus through the CRM1 export pathway. May act as suppressor of replication stress and chromosome missegregation.
Alternative names
RKHD2, RNF194, BM-013, MEX3C, RNA-binding E3 ubiquitin-protein ligase MEX3C, RING finger and KH domain-containing protein 2, RING finger protein 194, RING-type E3 ubiquitin transferase MEX3C