MAGP2

May play a role in hematopoiesis. In the cardiovascular system, could regulate growth factors or participate in cell signaling in maintaining large vessel integrity (By similarity). Component of the elastin-associated microfibrils (PubMed:8557636).

Aortic aneurysm, familial thoracic 9

AAT9

A disease characterized by permanent dilation of the thoracic aorta usually due to degenerative changes in the aortic wall. It is primarily associated with a characteristic histologic appearance known as 'medial necrosis' or 'Erdheim cystic medial necrosis' in which there is degeneration and fragmentation of elastic fibers, loss of smooth muscle cells, and an accumulation of basophilic ground substance.

None

The disease is caused by variants affecting the gene represented in this entry.

Forms intermolecular disulfide bonds either with other MAGP-2 molecules or with other components of the microfibrils.

N- and O-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. O-glycan heterogeneity at Thr-54: HexHexNAc (major) and HexHexNAc + sulfate (minor).

Belongs to the MFAP family.

• Secreted
• Extracellular space
• Extracellular matrix

MAGP2, MFAP5, Microfibrillar-associated protein 5, MFAP-5, MP25, Microfibril-associated glycoprotein 2, MAGP-2

• entrezGene:8076
• omim:601103
• swissprot:Q13361

Proteins

Immunology & Infectious Disease

19612Da