Mfge8
Developmental stage
Isoform 1 and isoform 2 are detectable in mammary tissue from non-pregnant animals, with isoform 2 being predominant. Levels of isoform 1 increase during gestation and lactation while levels of isoform 2 decrease.
Domain
The F5/8 type C 2 domain mediates high-affinity binding to phosphatidylserine-containing membranes.
Function
Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction (By similarity). Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization.
Post-translational modifications
N-glycosylated. Isoform 1 also exists in both an O-glycosylated and a non-O-glycosylated form.
Tissue Specificity
Mammary epithelial cell surfaces and spermatozoan. Isoform 2 is present in brain, heart, kidney and spleen and at low levels in lung, liver, small intestine and testis.
Cellular localization
- Membrane
- Peripheral membrane protein
- Secreted
- Cytoplasmic vesicle
- Secretory vesicle
- Acrosome membrane
- Peripheral membrane protein
- Located in the acrosomal region of zona-pellucida bound sperm.
Alternative names
Lactadherin, MFGM, Milk fat globule-EGF factor 8, SED1, Sperm surface protein SP47, MFG-E8, MP47, Mfge8