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Mga

Developmental stage

Expressed at 9.5 dpc, 10 dpc and 10.5 dpc in the limb buds, branchial arches and the tail region.

Domain

Transcription repression is enhanced or dependent on the presence of the T-box DNA-binding domain.

Function

Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an activator. Binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence and seems to regulate MYC-MAX target genes. Suppresses transcriptional activation by MYC and inhibits MYC-dependent cell transformation. Function activated by heterodimerization with MAX. This heterodimerization serves the dual function of both generating an E-box-binding heterodimer and simultaneously blocking interaction of a corepressor.

Cellular localization

Alternative names

Kiaa4252, Mga, MAX gene-associated protein

swissprot:A2AWL7 swissprot:Q9QXJ5 swissprot:Q3TS36 entrezGene:29808