MGLL
Function
Converts monoacylglycerides to free fatty acids and glycerol (PubMed:19029917, PubMed:20079333, PubMed:21049984, PubMed:22969151, PubMed:24368842). Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (PubMed:19029917, PubMed:20079333, PubMed:21049984, PubMed:22969151, PubMed:24368842). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth (PubMed:20079333).
Pathway
Glycerolipid metabolism; triacylglycerol degradation.
Sequence Similarities
Belongs to the AB hydrolase superfamily. Monoacylglycerol lipase family.
Tissue Specificity
Detected in adipose tissue, lung, liver, kidney, brain and heart.
Cellular localization
- Cytoplasm
- Cytosol
- Membrane
- Peripheral membrane protein
Alternative names
Monoglyceride lipase, MGL, HU-K5, Lysophospholipase homolog, Lysophospholipase-like, Monoacylglycerol lipase, MAGL, MGLL