Monoacylglycerol Lipase/MGL

Converts monoacylglycerides to free fatty acids and glycerol (PubMed:17700715, PubMed:18096503, PubMed:19029917, PubMed:20554061, PubMed:20729846, PubMed:21454566, PubMed:9341166). Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (PubMed:17700715, PubMed:18096503, PubMed:19029917, PubMed:20554061, PubMed:20729846, PubMed:21454566, PubMed:9341166). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth (By similarity).

Glycerolipid metabolism; triacylglycerol degradation.

Belongs to the AB hydrolase superfamily. Monoacylglycerol lipase family.

Ubiquitous.

• Cytoplasm
• Cytosol
• Membrane
• Peripheral membrane protein

Monoglyceride lipase, MGL, Monoacylglycerol lipase, MAGL, Mgll

• swissprot:O35678

Proteins

Immunology & Infectious Disease

33388Da