Mgll
Function
Converts monoacylglycerides to free fatty acids and glycerol (PubMed:17700715, PubMed:18096503, PubMed:19029917, PubMed:20554061, PubMed:20729846, PubMed:21454566, PubMed:9341166). Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (PubMed:17700715, PubMed:18096503, PubMed:19029917, PubMed:20554061, PubMed:20729846, PubMed:21454566, PubMed:9341166). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth (By similarity).
Pathway
Glycerolipid metabolism; triacylglycerol degradation.
Sequence Similarities
Belongs to the AB hydrolase superfamily. Monoacylglycerol lipase family.
Tissue Specificity
Ubiquitous.
Cellular localization
- Cytoplasm
- Cytosol
- Membrane
- Peripheral membrane protein
Alternative names
Monoglyceride lipase, MGL, Monoacylglycerol lipase, MAGL, Mgll