MGP
Function
Associates with the organic matrix of bone and cartilage. Thought to act as an inhibitor of bone formation.
Involvement in disease
Keutel syndrome
KTLS
An autosomal recessive disorder characterized by abnormal cartilage calcification, peripheral pulmonary stenosis neural hearing loss and midfacial hypoplasia.
None
The disease is caused by variants affecting the gene represented in this entry.
Post-translational modifications
Requires vitamin K-dependent gamma-carboxylation for its function.
Sequence Similarities
Belongs to the osteocalcin/matrix Gla protein family.
Cellular localization
- Secreted
Alternative names
MGLAP, GIG36, MGP, Matrix Gla protein, Cell growth-inhibiting gene 36 protein