MGRN1
Domain
The RING finger is required for ubiquitin ligase activity.
Function
E3 ubiquitin-protein ligase. Mediates monoubiquitination at multiple sites of TSG101 in the presence of UBE2D1, but not of UBE2G1, nor UBE2H. Plays a role in the regulation of endosome-to-lysosome trafficking. Impairs MC1R- and MC4R-signaling by competing with GNAS-binding to MCRs and inhibiting agonist-induced cAMP production. Does not inhibit ADRB2-signaling. Does not promote MC1R ubiquitination. Acts also as a negative regulator of hedgehog signaling (By similarity).
Pathway
Protein modification; protein ubiquitination.
Post-translational modifications
Autoubiquitinated in vitro.
Cellular localization
- Early endosome
- The endosomal localization is dependent on the interaction with TSG101.
- Isoform 1
- Cytoplasm
- Cytosol
- Nucleus
- Translocation from the cytosol to the nucleus is seen only in the presence of MC1R and MC4R, but not TBXA2R. Excluded from nucleoli.
- Isoform 2
- Cytoplasm
- Cytosol
- Nucleus
- Translocation from the cytosol to the nucleus is seen only in the presence of MC1R and MC4R, but not TBXA2R. Excluded from nucleoli.
- Isoform 3
- Cytoplasm
- Cytosol
- Cell membrane
- Isoform 4
- Cytoplasm
- Cytosol
- Cell membrane
Alternative names
KIAA0544, RNF156, MGRN1, E3 ubiquitin-protein ligase MGRN1, Mahogunin RING finger protein 1, RING finger protein 156, RING-type E3 ubiquitin transferase MGRN1