MGST1

Function

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity.

Post-translational modifications

Peroxynitrite induces nitration at Tyr-93 which activates the enzyme.

Sequence similarities

Belongs to the MAPEG family.

Tissue specificity

Highly expressed in liver.

Cellular localization

• Microsome
• Mitochondrion outer membrane
• Peripheral membrane protein
• Endoplasmic reticulum membrane
• Multi-pass membrane protein

Alternative names

• Microsomal glutathione S-transferase 1
• Microsomal GST-1
• Microsomal GST-I
• GST12
• MGST1
• MGST

Database links

• entrezGene:4257
• omim:138330
• swissprot:P10620

Target type

Proteins

Molecular weight

17599Da