MGST3
Function
Displays both glutathione S-transferase and glutathione peroxidase activities toward oxyeicosanoids, as part of cellular detoxification as well as synthesis of bioactive metabolites (PubMed:36370807, PubMed:9278457). Catalyzes conjugate addition of reduced glutathione to the alpha, beta-unsaturated C=C carbonyl group of eisosanoids such as leukotriene A4 and 15-deoxy-Delta12,14-prostaglandin J2 to form GSH adducts relevant to the inflammatory response (PubMed:36370807, PubMed:9278457). Catalyzes glutathione-dependent reduction of eicosanoid peroxides to yield the corresponding eicosanoid hydroxides (PubMed:9278457).
Pathway
Lipid metabolism; leukotriene C4 biosynthesis.
Lipid metabolism; arachidonate metabolism.
Sequence Similarities
Belongs to the MAPEG family.
Tissue Specificity
Predominantly expressed in heart, skeletal muscle, and adrenal cortex. Also found in brain, placenta, liver, kidney, pancreas, thyroid, testis and ovary. Almost absent in lung, thymus and peripheral blood leukocytes. Expressed in mast cells.
Cellular localization
- Mitochondrion outer membrane
- Multi-pass membrane protein
Alternative names
GST-3, Glutathione peroxidase MGST3, LTC4 synthase MGST3, MGST3