MIB1

E3 ubiquitin-protein ligase that mediates ubiquitination of Delta (Dl) and Serrate (Ser) receptors, which act as ligands of Notch proteins. Positively regulates the Notch signaling by ubiquitinating the intracellular domain of Dl and Ser, leading to endocytosis of Dl and Ser receptors. Regulates a subset of Notch signaling events, including wing margin specification, leg segmentation and vein determination, that are distinct from those events requiring neuralize (neur) activity. Also modulates lateral inhibition, a neur- and Dl-dependent signaling event, suggesting a distinct but partially complementary function with neur.

Protein modification; protein ubiquitination.

Ubiquitous in the wing imaginal disk (at protein level).

• Cytoplasm
• Cell cortex
• Localizes at the apical cortex of cells.

mind-bomb, CG5841, mib1, E3 ubiquitin-protein ligase mind-bomb, Mind bomb homolog, RING-type E3 ubiquitin transferase mind-bomb, D-mib

• swissprot:Q9VUX2

Proteins

Immunology & Infectious Disease

129872Da